Post by Deleted on Jan 22, 2012 22:01:49 GMT -5
There is a lovely recent post by an 11 year DSer named Duffy over on duodenalswitch.com, reporting some interesting health problems she had and the solution:
www.duodenalswitch.com/forum/showthread.php?t=9598
In this post, Duffy talks about the vast improvement in her life when she wen gluten free, including solving her anemia problem. Helped her lose weight too.
So I did a quick bit of research on PubMed and found this:
www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=4619724&TO=RVN&Eng=1
And this:
Dig Liver Dis. 2011 Jun;43(6):448-53. Epub 2011 Jan 12.
Mild enteropathy as a cause of iron-deficiency anaemia of previously unknown origin.
Monzón H, Forné M, González C, Esteve M, Martí JM, Rosinach M, Mariné M, Loras C, Espinós JC, Salas A, Viver JM, Fernández-Bañares F.
Source
Department of Gastroenterology, Hospital Universitari Mútua Terrassa and Research Foundation Mútua Terrassa, Barcelona, Spain.
Abstract
BACKGROUND AND AIMS:
We assessed whether mild enteropathy with negative coeliac serology may be gluten-dependent, and a cause of iron-deficiency anaemia. In cases not responding to gluten-free diet, the role of Helicobacter pylori infection was evaluated.
METHODS:
55 consecutive unexplained iron-deficiency anaemia patients were included. In all of them we performed: HLA-DQ2/DQ8 coeliac genetic study, distal duodenum biopsies, and tests to assess H. pylori infection. A gluten-free diet or H. pylori eradication was used as indicated. Final diagnosis was established based on response to specific therapy after a 12-month follow-up period.
RESULTS:
Histological findings were: (1) group A (positive genetics): 21 Marsh I, 2 Marsh IIIA, 12 normal; (2) group B (negative genetics): 16 Marsh I, 4 normal. Final diagnosis of anaemia in patients with enteropathy were: group A, gluten-sensitive enteropathy, 45%; H. pylori infection, 20%; gluten-sensitive enteropathy plus H. pylori, 10%; other, 10%; unknown, 15%; group B, gluten-sensitive enteropathy, 10%; H. pylori infection, 0% (1 non-eradicated case, 10%); non-steroidal anti-inflammatory drug intake, 20%; other, 20%; unknown, 40% (p=0.033).
CONCLUSIONS:
Mild enteropathy is frequent in patients with unexplained iron-deficiency anaemia and negative coeliac serology. Most cases are secondary to either gluten-sensitive enteropathy or H. pylori infection, or both; however, there is also a substantial number of patients without a definitive diagnosis.
So, as DSers may have increased gluten sensitivity, as well as issues with overgrowth of bacteria (including H. pylori, especially those of us taking a PPI), perhaps this is a factor in our inability to absorb iron, and perhaps weight gain?
I'm not quite ready to change up my diet as severely as going gluten-free requires, but it's a thought.
www.duodenalswitch.com/forum/showthread.php?t=9598
In this post, Duffy talks about the vast improvement in her life when she wen gluten free, including solving her anemia problem. Helped her lose weight too.
So I did a quick bit of research on PubMed and found this:
www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=4619724&TO=RVN&Eng=1
And this:
Dig Liver Dis. 2011 Jun;43(6):448-53. Epub 2011 Jan 12.
Mild enteropathy as a cause of iron-deficiency anaemia of previously unknown origin.
Monzón H, Forné M, González C, Esteve M, Martí JM, Rosinach M, Mariné M, Loras C, Espinós JC, Salas A, Viver JM, Fernández-Bañares F.
Source
Department of Gastroenterology, Hospital Universitari Mútua Terrassa and Research Foundation Mútua Terrassa, Barcelona, Spain.
Abstract
BACKGROUND AND AIMS:
We assessed whether mild enteropathy with negative coeliac serology may be gluten-dependent, and a cause of iron-deficiency anaemia. In cases not responding to gluten-free diet, the role of Helicobacter pylori infection was evaluated.
METHODS:
55 consecutive unexplained iron-deficiency anaemia patients were included. In all of them we performed: HLA-DQ2/DQ8 coeliac genetic study, distal duodenum biopsies, and tests to assess H. pylori infection. A gluten-free diet or H. pylori eradication was used as indicated. Final diagnosis was established based on response to specific therapy after a 12-month follow-up period.
RESULTS:
Histological findings were: (1) group A (positive genetics): 21 Marsh I, 2 Marsh IIIA, 12 normal; (2) group B (negative genetics): 16 Marsh I, 4 normal. Final diagnosis of anaemia in patients with enteropathy were: group A, gluten-sensitive enteropathy, 45%; H. pylori infection, 20%; gluten-sensitive enteropathy plus H. pylori, 10%; other, 10%; unknown, 15%; group B, gluten-sensitive enteropathy, 10%; H. pylori infection, 0% (1 non-eradicated case, 10%); non-steroidal anti-inflammatory drug intake, 20%; other, 20%; unknown, 40% (p=0.033).
CONCLUSIONS:
Mild enteropathy is frequent in patients with unexplained iron-deficiency anaemia and negative coeliac serology. Most cases are secondary to either gluten-sensitive enteropathy or H. pylori infection, or both; however, there is also a substantial number of patients without a definitive diagnosis.
So, as DSers may have increased gluten sensitivity, as well as issues with overgrowth of bacteria (including H. pylori, especially those of us taking a PPI), perhaps this is a factor in our inability to absorb iron, and perhaps weight gain?
I'm not quite ready to change up my diet as severely as going gluten-free requires, but it's a thought.
